Volume 1, No. 1, July 2017

Contents

REVIEW ARTICLES

GERTRUDE-EMILIA COSTIN, Advances in science: next generation of lab tools, models and testing platforms used in predictive toxicology

ROSHANAK ASLEBAGH, KELLY L. WORMWOOD, DEVIKA CHANNAVEERAPPA, EMMALYN J. DUPREE, IZABELA SOKOLOWSKA, ARMAND G. NGOUNOU WETIE, SAPAN PATEL, MARIUS MIHASAN, ALISA G. WOODS, COSTEL C. DARIE, Proteomics of the Post-translational Modifications: the knowns and the unknowns

CRISTINA-SORINA CATANA, DIANA GULEI, IOANA BERINDAN-NEAGOE, New insights into the role of non-coding RNAs as transcriptional targets of p53

DIANA GULEI, IOANA BERINDAN-NEAGOE, GEORGE A CALIN, MicroRNAs: beating cancer with new powerful weapons

LIVIA ELENA SIMA, SALVATORE CONDELLO, DANIELA ELENA MATEI, New therapeutic targets in ovarian cancer stem cells

SORIN TUNARU, Strategies for G-protein coupled receptor deorphanization

MINI REVIEW ARTICLES

ADRIAN CRISTIAN ROBU, LAURENTIU POPESCU, ALINA DIANA ZAMFIR, Actual trends in mass spectrometry of glycosaminoglycans

Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts...

Saravanakkumar Chennappan, Tanja Schulze, Ion Cristian Cirstea
Oncogenic H-Ras germline mutations are associated with Costello syndrome (CS), a developmental disorder characterised by the failure to thrive, skin and musculoskeletal abnormalities, cardiomyopathy, and susceptibility to tumour d

Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult...

Jayhun Lee and Tudorita Tumbar
Cellular plasticity for fate acquisition is associated with distinct chromatin states, which include histone modi cations, dynamic association of chromatin factors with the DNA, and global chromatin compaction and nuclear organiza

Advances in science: next generation of lab tools, models and testing...

Gertrude-Emilia Costin
Toxicology testing platforms represent the basis of the human health risk assessment process that determines whether a material or product may induce harm to humans upon exposure. Historically, safety assessment of raw ingredients

Proteomics of the post-translational modifications: the knowns and the unknowns

Roshanak Aslebagh, Kelly L. Wormwood, Devika Channaveerappa, Emmalyn J. Dupree, Izabela Sokolowska, Armand G. Ngounou Wetie, Sapan Patel, Marius Mihasan, Alisa G. Woods, Costel C. Darie
Great progress has been made in identification and characterization of proteins by mass spectrometry-based proteomics, but there is still a great challenge to identify and characterize post-translational modifications (PTMs) withi

New insights into the role of non-coding RNAs as transcriptional targets...

Cristina-Sorina Catana, Diana Gulei, Ioana Berindan-Neagoe
P53 classifies as one of the main tumor suppressor gene and the identification of its direct transcriptional targets such as certain non-coding RNAs (ncRNAs) is important for understanding the development and progression of cancer

MicroRNas: beating cancer with new powerful weapons

Diana Gulei, Ioana Berindan-Neagoe, George A Calin
MicroRNAs have become central players in the process of finding and implementing novel therapeutic strategies for the overcoming of the cancer associated heterogeneous effects. Their ability to target multiple coding genes in orde

New therapeutic targets in ovarian cancer stem cells

Livia Elena Sima, Salvatore Condello, Daniela Elena Matei
Ovarian cancer (OC) is the deadliest gynecological malignancy. Characterized by frequent recurrences after standard chemotherapy and a pattern of dissemination in the peritoneal cavity, ovarian tumor development and progression ma

Strategies for G-protein coupled receptor deorphanization

Sorin Tunaru
G-protein coupled receptors (GPCRs) form the largest group of transmembrane proteins in mammals, and they are major regulators of multiple cellular processes. Intense research performed in the last decades revealed their implicati

Actual trends in mass spectrometry of glycosaminoglycans

Adrian Cristian Robu, Laurentiu Popescu, Alina Diana Zamfir
During the past few years, in the field of glycosaminoglycomics, mass spectrometry (MS) emerged as one of the most efficient analytical techniques due to its valuable contribution to compositional and structural determination of v

Editor-in-Chief: OCTAVIAN POPESCU

Deputy Editor-in-Chief: ŞTEFANA-MARIA PETRESCU

Editorial team members: ALEXANDRU ALMĂŞANU (Cleveland, USA), RADU ARICESCU (Oxford, UK), DORINA AVRAM (Gainesville, USA), MIHAIL BARBOIU (Montpellier, France), MIHNEA BOŞTINĂ (Otago, New Zealand), GEORGE CĂLIN (houston, USA), MIHAI CIUBOTARIU (New Haven, USA), ŞTEFAN CONSTANTINESCU (Brussels, Belgium), GERTRUDE COSTIN (Gaithersburg, USA), ANETTE DAMERT (Cluj-Napoca, Romania), SORIN DRĂGHICI (Detroit, USA), JEAN DUBUISSON (Lille, France), ILEANA FĂRCĂŞANU (Bucharest, Romania), ELENA GANEA (Bucharest, Romania), MIRCEA IVAN (Indianapolis, USA), GABRIELA NEGROIU (Bucharest, Romania), NORICA NICHITA (Bucharest, Romania), ANDREI PETRESCU (Bucharest, Romania), FRANCES PLATT (Oxford, UK), ANCA ROŞEANU (Bucharest, Romania), OVIDIU SIRBU (Timisoara, Romania), DAN SIMIONESCU (Clemson, USA), CARMEN SOCACIU (Cluj-Napoca, Romania), ŞTEFAN SZEDLACSEK (Bucharest, Romania)

Editorial Secretary: ROXANA TUDOR

Computer Editing: SIMONA VERMAN