Molecular Life (Mol.Life) is a peer-reviewed journal which publishes original research papers, reviews and short communications on topics of high interest to researchers in molecular life sciences.
Call for Papers
The Editorial Board of Molecular Life is pleased to invite submission of research papers on the topics covered by the journal: biochemistry and connected fields, such as cellular and molecular biology, molecular immunology, intracellular signaling, biophysics and bioinformatics, genomics, proteomics. Submitted articles will be reviewed and papers will be published on line immediately upon acceptance.
Volume 3, No. 1, November 2019
Molecular evolution, structure and activation of legumains, asparagine-specific proteinases
Andrei Shutov, Irina Kakhovskaya, Karl Wilson Evolutionary analysis of eukaryote legumains was conducted using sequences of their precursors composed of Asparaginyl EndoPeptidase (AEP) domain, Legumain Stabilization and Activity Modulation (LSAM) domain, and Activation Peptid [...]
Radiobiological effects of pulsed, high dose-rate particle beams generated by high-power lasers
M. Bobeica, T. Asavei, V. Nastasa, P. R. Vasos As intense laser sources are constructed around the world, various applications are developed and thus, in the medical field it is foreseen to use laser-driven radiation for cancer diagnostic and radiotherapy. High-power lasers ca [...]
Volume 2, No. 1, July 2018
Mutants in the Fe-S biogenesis component AtDRE2 develop twin embryos and are defective in...
Diana Mihaela Buzas, Tetsu Kinoshita Iron is assembled inside cells into cofactors, essential for biological functions. Two types of cofactors, Iron Sulfur clusters and diferric tyrosyl radicals, share a conserved assembly complex containing the DRE2 enzyme, essentia [...]
Lineage-specific evolution of SVA and LAVA retrotransposons
Annette Damert SVA (SINE-R-VNTR-Alu) and LAVA (L1-Alu-VNTR-Alu) are composite non-autonomous non-LTR retrotransposons specific to hominoid primates. They are mobilized by the LINE-1-encoded protein machinery in trans. SVA insertions can cause di [...]
Targeting the epithelial growth factor receptor in head and neck tumours: current status and...
Loredana G. Marcu While locoregional control in head and neck cancer has improved over the last few decades because of advances in imaging and treatment technology, five-year survival rates are still poor due to tumour resistance to treatment, recu [...]
Limited proteolysis initiates massive degradation of ginnacin, storage 11S globulin from Ginkgo seeds
Alla Cherdivară, Angela Rudakova, Tatiana Stepurina, Sergei Rudakov, Karl Wilson, Andrei Shutov Limited proteolysis of α-chains, followed by a deep cleavage of αβ-subunits via one-by-one mechanism, is observed in the course of papain hydrolysis of ginnacin, the storage 11S globulin from Ginkgo biloba seeds. An independent an [...]
Volume 1, No. 1, July 2017
Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello...
Saravanakkumar Chennappan, Tanja Schulze, Ion Cristian Cirstea Oncogenic H-Ras germline mutations are associated with Costello syndrome (CS), a developmental disorder characterised by the failure to thrive, skin and musculoskeletal abnormalities, cardiomyopathy, and susceptibility to tumour d [...]
Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle...
Jayhun Lee and Tudorita Tumbar Cellular plasticity for fate acquisition is associated with distinct chromatin states, which include histone modi cations, dynamic association of chromatin factors with the DNA, and global chromatin compaction and nuclear organiza [...]
Advances in science: next generation of lab tools, models and testing platforms used in...
Gertrude-Emilia Costin Toxicology testing platforms represent the basis of the human health risk assessment process that determines whether a material or product may induce harm to humans upon exposure. Historically, safety assessment of raw ingredients [...]
Proteomics of the post-translational modifications: the knowns and the unknowns
Roshanak Aslebagh, Kelly L. Wormwood, Devika Channaveerappa, Emmalyn J. Dupree, Izabela Sokolowska, Armand G. Ngounou Wetie, Sapan Patel, Marius Mihasan, Alisa G. Woods, Costel C. Darie Great progress has been made in identification and characterization of proteins by mass spectrometry-based proteomics, but there is still a great challenge to identify and characterize post-translational modifications (PTMs) withi [...]
New insights into the role of non-coding RNAs as transcriptional targets of p53
Cristina-Sorina Catana, Diana Gulei, Ioana Berindan-Neagoe P53 classifies as one of the main tumor suppressor gene and the identification of its direct transcriptional targets such as certain non-coding RNAs (ncRNAs) is important for understanding the development and progression of cancer [...]